CESB 2024


15. – 18.09.2024, NUREMBERG (GERMANY)

Photo Christophe Marquette

Christophe A. Marquette

Deputy Director of the Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, Université Lyon, France

Presentation title:
Bioinspired hydrogels for 3D bioprinting and regenerative medicine

Christophe Marquette received the Doctorat de spécialité in Biochemistry (1999) from the Université Claude Bernard-Lyon 1. After a two years post-doctoral fellowship at the Concordia University (Canada, Qc), he integrated the Centre National de la Recherche Scientifique (CNRS) in 2001.
He is presently permanent Research Director and Deputy Director at the Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS, UMR5246, CNRS-Université Lyon1) and is in charge of the Biochips and Micro-arrays Group, dealing with biology/surface interaction and 3D printing of living cells. Since 1998, he is author or co-author of more than 160 articles (H index: 44), 15 book chapters, 25 patents and more than 200 communications.
He is also the founder the Nano-H, AXO Science, HealShape and 3Deus Dynamics Companies.
He is also the founder of the unique 3d.FAB platform, specialised in additive manufacturing technologies for Life Science (http://fabric-advanced-biology.univ-lyon1.fr/).

Katja Schenke-Layland

Katja Schenke-Layland

Institute of Biomedical Engineering, Department for Medical Technologies and Regenerative Medicine, Eberhard Karls University Tübingen, Tübingen, Germany
Natural and Medical Sciences Institute (NMI) at the University of Tübingen, Reutlingen, Germany

Presentation title:
Extracellular Matrix Proteins Nidogen-1 and Decorin Mitigate Ischemia and Restore Functionality of Human Islets of Langerhans

Professor Dr. Katja Schenke-Layland is currently the Co-Editor-In-Chief of Tissue Engineering Part B (Mary Ann Liebert) and Executive Editor of Advanced Drug Delivery Reviews (Elsevier), as well as on several editorial boards such as Matrix Biology (Elsevier), Current Opinion in Biomedical Engineering (Elsevier), and Journal of 3D Printing in Medicine (Future Medicine). She is a fellow/ board member of the German National Academy of Science and Engineering (acatech), German Central Ethics Committee for Stem Cell Research (ZES), International and German Societies of Matrix Biology, and the European Alliance for Medical and Biological Engineering and Science (EAMBES). Professor Dr. Katja Schenke-Layland studied biology, sociology and psychology at the Friedrich Schiller University in Jena. There she received her PhD in Biology in Cardiovascular Tissue Engineering in 2004. She received a postdoctoral research fellowship at the Saban Research Institute of the Children’s Hospital at the University of Southern California in Los Angeles (2004-2005) and following this she received another postdoctoral research fellowship at the David Geffen School of Medicine at the University of California Los Angeles UCLA, USA (2005-2008). In 2008, she was appointed Assistant Research Professor in the Department of Medicine/Cardiology at UCLA and is currently an Adjunct Associate Professor. In January 2010, she became group leader of the Fraunhofer Attract Group at the Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB), Department of Cell and Tissue Engineering in Stuttgart, Germany, and later assumed the position of department head. From 2016 to 2017, she was acting institute director of the Fraunhofer IGB before then joining the NMI in 2018.

Extracellular Matrix Proteins Nidogen-1 and Decorin Mitigate Ischemia and Restore Functionality of Human Islets of Langerhans

Abiramy Jeyagaran, Max Urbanczyk, Shannon L. Layland1, Katja Schenke-Layland1,2

1 Institute of Biomedical Engineering, Department for Medical Technologies and Regenerative Medicine, Eberhard Karls University Tübingen, 72076 Tübingen, Germany
2 Natural and Medical Sciences Institute (NMI) at the University of Tübingen, Reutlingen, Germany
§ Authors contributed equally.

Transplantation of donor islets of Langerhans is a potential therapeutic approach for patients with diabetes mellitus; however, its’ success is limited by islet death and dysfunction during the initial hypoxic conditions at the transplantation site,[1] emphasizing the importance of supporting the donor islets in the days post-transplantation until the site is vascularized. We previously demonstrated that the extracellular matrix (ECM) proteins nidogen-1 (NID1)[2] and decorin (DCN)[3] improved the functionality and survival of the β-cell line, EndoC-βH3, and the viability of human islets post-isolation.[4]  To advance the use of these ECM proteins in a clinical application, we assessed the effects of ECM proteins NID1 and DCN on isolated human donor islets cultured in normoxic and hypoxic conditions. Interestingly, NID1- and DCN-treatment restored β-cells functionality of human donor islets in a hypoxic environment. Furthermore, TUNEL staining for DNA fragmentation as a marker of cell apoptosis showed that in the hypoxic cultures, NID1 or DCN-treatment significantly reduced DNA fragmentation compared to the control islets. Our results demonstrate that the co-transplantation of these ECM proteins with islets of Langerhans may have the potential to overcome the hypoxia-induced cell death observed post-transplantation and improve transplant outcomes.

[1] H. Komatsu, F. Kandeel, Y. Mullen, Pancreas 2018, 47, 533.
[2] A. Zbinden, S. L. Layland, M. Urbanczyk, D. A. C. Berrio, J. Marzi, M. Zauner, A. Hammerschmidt, E. M. Brauchle, K. Sudrow, S. Fink, et al., 2020, 2002500, 1.
[3] M. Urbanczyk, A. Jeyagaran, A. Zbinden, C. en Lu, J. Marzi, L. Kuhlburger, S. Nahnsen, S. L. Layland, G. Duffy, K. Schenke-Layland, Matrix Biol. 2023, 115, 160.
[4] D. Brandhorst, H. Brandhorst, S. L. Layland, S. Acreman, K. Schenke-Layland, P. R. V Johnson, Acta Biomater 2022, 137, 92.

Maria Chatzinikolaidou
Maria Chatzinikolaidou Associate Professor of Biomaterials in Bioengineering and Head of the Laboratory for Biomaterials in Tissue Engineering at the Department of Materials Science and Technology at the University of Crete, Greece

Dr. Maria Chatzinikolaidou, FBSE, FTERM, is an Associate Professor of Biomaterials in Bioengineering and Head of the Laboratory for Biomaterials in Tissue Engineering at the Department of Materials Science and Technology at the University of Crete (https://www.materials.uoc.gr/en/faculty/maria-chatzinikolaidou/), and affiliated faculty member at Foundation for Research and Technology – Hellas (FORTH). Her research interests focus on the development of biomaterials and scaffolds for tissue engineering applications including bone, dental, cardiovascular, and the validation of their in vitro and in vivo biocompatibility, functionality and biomechanical characteristics.
Dr. Chatzinikolaidou served as vice president of the executive board of the Hellenic Society for Biomaterials in the terms 2015-2018 and 2022-2025. She served as chair of the 28th Conference of the European Society for Biomaterials (ESB 2017) held in Athens, and program chair of the TERMIS-EU 2019 conference held in Rhodes in Greece. She is a Fellow in Biomaterials Science and Engineering (FBSE, elected 2020) of the International Union of Societies for Biomaterials Science and Engineering (IUS-BSE) and International Fellow of Tissue Engineering and Regenerative Medicine (FTERM, elected 2023). In 2023 she has been elected European Orthopaedic Research Society (EORS) ambassador for Greece.

Foto Dirk

Dirk W. Grijpma

University of Twente, The Netherlands

Presentation title:
Synthesis and properties of biodegradable hybrid networks based on natural and synthetic polymers

Prof. Dirk Grijpma’s research interests are: resorbable polymers for medical applications, structure-properties relationships in polymers, tissue engineering, bioreactor technology, drug delivery, ring opening polymerization, photo-polymerization, 3D-printing and stereolithography. He is highly interested in translation of his research to clinical application.

His work includes the synthesis and characterization of large arrays of materials in a combinatorial manner and their evaluation by high throughput methods, which have led to the discovery of novel hydrogel materials that performed unexpectedly well in their interaction with cells. The development of hybrid biomaterials based on (incompatible) natural and synthetic polymers yields exciting new materials that combine the beneficial properties of both.

Jürgen Groll Department for Functional Materials in Medicine and Dentistry, University of Würzburg, Germany Presentation title: The collaborative research center SFB/TRR 225 biofabrication – a general overview and specific research examples
Jürgen Groll received his Ph.D. in 2004 from the RWTH Aachen (Germany) with summa cum laude after working under the guidance of Martin Möller. From 2005 to 2009, he worked in industry at SusTech GmbH & Co KG (Darmstadt, Germany) in the field of functional coatings and nanotechnology. In parallel, he built up a research group on polymeric biomaterials at the DWI interactive materials research institute in Aachen (Germany). Since 2010 he is full Professor (W3) and holds the chair for Functional Materials in Medicine and Dentistry at the University of Würzburg. His research interest comprises applied polymer chemistry, nanobiotechnology, bioinspired materials and scaffolds, immunomodulation and biofabrication. From 2012 to 2017, he coordinated the large-scale integrated European project HydroZONES (contract no 309962) and was awarded an ERC consolidator grant (Design2Heal, contract no° 617989) in 2013 as well as an ERC proof-of-concept grant (Design2Flow, contract no 899609) in 2019. He currently is spokesman of the Collaborative research Center TRR 225 “From the fundamentals of biofabrication towards functional tissue models” (http://trr225biofab.de/), an integrated funding scheme of the German Research Foundation (DFG) that has started January 2018 and is now running in the second funding phase between the Universities of Würzburg, Bayreuth and Erlangen-Nürnberg, comprising 20 research projects that are guided by 36 PIs. He also acts as managing director of the Institute of Functional Materials and Biofabrication (IFB) and leads the Center of Polymers for Life (CPL), both institutions of the university of Würzburg. He has published over 250 papers in peer-reviewed scientific journals (ORCID-ID: 0000-0003-3167-8466).
Zhen Gu

Zhen Gu

Distinguished Chair Professor and Dean, College of Pharmaceutical Sciences, Zhejiang University, PR China

Dr. Zhen Gu is a Qiushi Distinguished Chair Professor and Dean of College of Pharmaceutical Sciences at Zhejiang University. He also serves as the Director of the National Key Laboratory of the Advanced Drug Delivery and Release Systems. Dr. Gu received his B.S. degree in Chemistry and M.S. degree in Polymer Chemistry and Physics from Nanjing University. In 2010, he obtained Ph.D. from the Department of Chemical and Biomolecular Engineering at UCLA. He was a Postdoctoral Associate working with Dr. Robert Langer at MIT and Harvard Medical School during 2010 to 2012. Before he moved to Zhejiang University in 2020, he was a Full Professor in the Department of Bioengineering and Director of the NIH Biotechnology Training in Biomedical Sciences and Engineering Program at UCLA. From 2012 to 2018, he was working in the Joint Department of Biomedical Engineering at the University of North Carolina at Chapel Hill and North Carolina State University, where he had been appointed as a Jackson Family Distinguished Professor. Dr. Gu’s group studies controlled drug delivery, biomaterials and cell therapy. He has published over 240 research papers and applied over 150 patents. He is the recipient of the Felix Franks Medal of the Royal Society of Chemistry (2020), Young Investigator Award of Controlled Release Society (2017), Sloan Research Fellowship (2016) and Pathway Award of the American Diabetes Association (2015). MIT Technology Review listed him in 2015 as one of the top innovators under the age of 35. He was elected to the College of Fellows of the American Institute for Medical and Biological Engineering (AIMBE) in 2019 and the International Academy of Medical and Biological Engineering (IAMBE) in 2021. Dr. Gu serves as an Associate Editor for Science Advances, Nano Research and Regenerative Biomaterials.

Hua Ai

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, PR China

Presentation title (tentative):
Magnetic resonance imaging nanoprobes

Dr. Hua Ai is currently a Professor at the National Engineering Research Center for Biomaterials, Sichuan University; and an Adjunct Professor of Radiology, West China Hospital, Sichuan University. Dr. Ai is an elected Fellow of Biomaterials Science and Engineering (FBSE), the Chinese Society for Biomaterials (FCSBM), and the American Institute for Medical and Biological Engineering (FAIMBE). Dr. Ai serves on a few editorial boards including Biomaterials, JBMR-A, Regenerative Biomaterials, etc. He also serves on the Board of Governors for Acta Materialia, Inc. Dr. Ai is focusing on design and application of magnetic nanobiomaterials for molecular imaging and drug delivery. He developed sensitive magnetic resonance imaging probes based on superparamagnetic iron oxide nanoparticles and paramagnetic molecules. One of his probes is archived in Molecular Imaging and Contrast Agent Database (NIH’s National Library of Medicine). Most of his work was carried out under clinical magnetic resonance imaging scanners. Besides, Dr. Ai is active in promoting international biomaterials academic exchanges through organizing meetings, symposia and workshops, and currently he is a committee member of the International Union of Societies for Biomaterials Science and Engineering.
Xingyu Jiang

Xingyu Jiang

Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, PR China

Presentation title:
Stretchable bio-electronics for regenerative medicine

Xingyu Jiang is a Chair Professor at the Southern University of Science and Technology, Shenzhen, China. He obtained his B.S. at the University of Chicago in 1999 and his Ph.D. at Harvard University in 2004. In 2005, he started a lab at the National Center of NanoScience&Technology (Chinese Academy of Sciences). In 2018, he moved to the Southern University of Science and Technology. He has published more than 400 peer-reviewed papers. His research has been recognized by many awards and supported by a number of funds, including National Science Foundation of China’s Distinguished Young Scholars Award, and the Human Frontier Science Program Young Investigator Award. He is a Fellow of the Royal Society of Chemistry (UK) and the American Institute of Medical and Biological Engineering.
This talk showcases advancements in using biodegradable, stretchable electronics, fabricated with micropatterning liquid metal (based on Gallium) encapsulated in elastic polymers, to achieve blood vessel regeneration. Conductive inks made from lipid metals-polymer composites (MPC) can be encapsulated within elastomer-based microfluidic channels that serve as conducting wires that are flexible, stretchable and completely biodegradable. MPCs are applicable to stringent requirements imposed by biomaterials for regeneration, by being completely biocompatible and stretchable, MPCs integrate seamlessly with living tissues. These properties can dramatically expand the capability of electronic devices as biomedical sensors, as well as actuators for controllable movement of cells and gene therapy. MPC-based epidermal electronics, such as blood oxygen sensors and sweat detection devices, allow real-time health monitoring. Implanted MPCs can form “electronic blood vessels” that integrates sensing with regeneration in model animals. Electrophysiological measurement such as EEG ECG EMG can be conveniently measured over long periods of time.
Christina Martins

Cristina Martins

BioEngineered Surfaces Group Leader
INEB – Instituto de Engenharia Biomedica
i3S- Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal

Presentation title:
Bioengineered biomaterial coatings based on antimicrobial peptides to fight bacterial infections

Cristina Martins (Martins, MCL) is an expert in the development of biomaterial coatings designed at the nanoscale using self-assembled monolayers (SAMs) and biomedical polymers. She is Principal Investigator at INEB/ i3S (Instituto Engenharia Biomédica/Instituto de Investigação e Inovação em Saúde; www.i3s.up.pt) and Invited Assistant Professor at the University of Porto, Portugal (ICBAS – Instituto de Ciências Biomédicas Abel Salazar). Cristina Martins is the leader of the research group: BioEngineered Surfaces. Her group is investigating the effect of surface immobilized ligands (proteins/peptides, fatty acid like and glycosylated compounds) in the guiding of specific protein/cell binding to control bacterial infection (e.g., in gastric and skin infection or osteomyelitis prevention) and/or medical devices associated thrombus formation.
Scopus Author ID: 7402262354;

QL-passport photo

Ling Qin

Choh-Ming Li Professor of Orthopaedics & Traumatology, Cologne, Germany
Director of Innovative Orthopaedic Biomaterials and Drug Translational Research Laboratory of Li Ka Shing Institute of Health Sciences, Faculty of Medicine
Director of Centre of Musculoskeletal Degeneration and Regeneration/Director of Musculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology
The Chinese University of Hong Kong, Hong Kong SAR, PR China

Presentation title:
Magnesium as an exogenous growth factor in regulation of skeletal regeneration via upregulation of endogenous growth factors

Professor Ling QIN is Choh-Ming Li Professor of Orthopaediatrics and Traumatology and Director of CUHK SZ-HK Innovation Technology Institute (Futian) and Musculoskeletal Research Laboratory of the Department of Orthopaedics & Traumatology. Professor Qin has been working on basic and translation research in orthopaedics with focus on diagnosis and pathophysiology of bone metabolic disorders and their treatment using innovative biometals as Class III medical implants over the past 30 years. Professor Qin is editor-in-chief of Journal of Orthopaedic Translation and past president of International Chinese Musculoskeletal Research Society (ICMRS). As principle investigator, Dr. Qin has received over 36 competitive research grants (including AoE, TRS, CRF, GRF, ITF, HMRF, NSFC-RGC from Hong Kong, and EU-NSFC, 12.5 and 13.5 Key R&D projects of the MOST from Mainland). Professor Qin published 9 books and over 460 SCI journal papers with a H-index of 76. He also holds over 30 inventions or new utility patents from PRC and USA. His pioneer scientific and translational research work in developing innovative biodegradable Mg-based metals for orthopaedic applications has been highlighted in Nature and Science.

Professor QIN received many prestigious honors and awards, including Member of Academy of Europe (MAE) and Fellow of AIMBE, ICORS, ASBMR, and IUSBSE attributed to his contribution to musculoskeletal research and innovation of biomaterials for orthopaedic applications.

Laura Russo

University of Milano-Bicocca, School of Medicine and Surgery, Vedano al Lambro, Italy

Presentation title:
The importance of Glycosignature in ECM tissue models

Laura Russo is Associate Professor at University of Milano-Bicocca and her research is focused on biomaterials for the development of multifunctional medical devices, including 3D in vitro tissue models, regenerative medicine and patient-personalized biosensors. Her research experience dates to 2010, as PhD student in the BioOrganic research group of the University of Milano-Bicocca, developing n a multidisciplinary project exploiting glycoscience in the field of nano- and biomaterials for tissue engineering. In 2010 LR was Visiting Researcher at Imperial College of London, studying hybrid bioglass based biomaterials for osteochondral tissue regeneration. From 2013 to 2015, as Post Doc Fellow, at University of Milano-Bicocca, she was unit coordinator of a research project on smart biomaterials for organoid cell cultures for cardiac tissue engineering. In October 2016 LR awarded a SFI Starting Investigator Research Grant (SIRG) at Cùram, National University of Ireland – Galway – where she started her research as Principal Investigator on Glycoconjugates biomaterials for tissue engineering applications and cell biology studies. In March 2017 she got a position of Assistant professor at the University of Milano – Bicocca and maintained the position of visiting researcher at Cùram. She was also appointed Adjunct Lecturer at the National University of Ireland – Galway. LR has awarded the prestigious Junior Research Award for Organic Chemistry in Life Science of the Italian Chemical Society for her scientific contribution on organic chemistry applied to the life science field. From 2022 LR is Associate Professor at University of Milano-Bicocca, Member of the Scientific Advisory Board of Biocompatibility Innovation (BCI) and founder of Resyde srl – start-up companies in the field of implantable medical devices. LR is member of the Editorial Advisory Board of Chemistry Europe – Wiley; the Board of Assistant Editors of Journal of Materials Science: Materials in Medicine – Springer Nature; the Editorial Board of Organic Materials – Thieme Verlag KG.
mss - photo 2024

Manuel Salmeron-Sanchez

James Watt School of Engineering
Centre for the Cellular Microenvironment
Advanced Research Centre, Glasgow
University of Glasgow, UK

Presentation title:
Engineered viscoelasticity in stem cell microenvironments

Manuel Salmeron-Sanchez is Professor of Biomedical Engineering at the University of Glasgow Glasgow and ICREA Research Professor at Institut de Bioenginyeria de Catalunya (IBEC). Manuel develops advanced biomaterials for cell and tissue engineering, to underpin in vitro models and as tools for mechanobiology. His group engineers materials to provide control of the local cellular microenvironment, both biochemically and biophysically, including materials that trigger the organisation of extracellular matrix proteins in a physiological way (Science Advances 2016); the use viscosity to control cell behaviour (PNAS 2018); living biomaterials (bacteria-based materials) for stem cell engineering (Advanced Materials 2018); the low dose use of BMP-2 for bone regeneration (Advanced Science 2019) and interfaces that trigger the mechanical activation of growth factors (Advanced Materials 2024). Manuel holds an ERC AdG to develop the next generation of viscoelastic materials to understand this important property of the extracellular matrix in the context of tissue regeneration. Manuel was Professor of Applied Physics in Valencia until his relocation to Glasgow in 2013 as Chair of Biomedical Engineering. He is a Fellow of the Royal Society of Edinburgh, Scotland’s National Academy for Arts and Sciences.

Helder A. Santos

Hélder A. Santos

Head of the Department of Biomaterials and Biomedical Technology, University Medical Center Groningen, University of Groningen, The Netherlands
Head of the Translational Bionanomicro Theragenerative Medicine Lab, University Medical Center Groningen, University of Groningen, The Netherlands
Scientific Director of the Health Technology Research and Innovation Cluster
Director and Head of the Nanomedicine and Biomedical Engineering Lab, Faculty of Pharmacy, University of Helsinki, Finland

Presentation title:
Biomimetic Cloaked Nanobiomaterials for Controlled Drug Delivery and Tissue Repair and Regeneration

Prof. Santos (D.Sc. Tech., Chem. Eng.) is a Full Professor and Chair in Biomedical Engineering, and the Head of the Department of Biomaterials and Biomedical Technology, University Medical Center Groningen, University of Groningen. He is also Research Director at the University of Helsinki, Faculty of Pharmacy. Prof. Santos is also the co-founder of the startups Capsamedix Oy and Medixmicro Oy, and Coordinator of a large MSCA-ITN P4 FIT network in tendon repair. He holds Visiting Professorships at the Shanghai Jiao Tong University School of Medicine and University of Tartu, and he is also an Honorary Adjunct Fellow at the University of Technology Sydney. Prof. Santos research interests include the development of nanoparticles/nanomedicines and biomaterials for biomedical applications, particularly cancer and heart diseases. His lab makes the unique bridge between medical engineering, pharmaceutical nanotechnology, and tissue engineering by combining unique techniques to develop novel therapeutic formulations for translation into the clinic. He is co-author of more than 550 publications (+24000 citations; h-index = 91) and 6 patents. He has +250 invited talks around the world. He is also in Editorial board member of Advanced Healthcare Materials, Advanced Therapeutics, Chemical Society Reviews, Journal of Controlled Release, VIEW, Journal of Functional Materials, Frontiers in Bioengineering and Biotechnology and Materials, Frontiers in Biomaterials, Precision Nanomedicine, among many others. He is Associate Editor of Nano Select, Smart Materials in Medicine, and Drug Delivery and Translational Research, among others. Prof. Santos has received prestigious honours, awards and grants, such as the “Talent Prize in Science” in 2010 attributed by the Portuguese Government, the European Research Council Starting Grant in 2013, the European Research Council Proof-of-Concept Grant in 2018, the Young Researcher Award in 2013 attributed by the University of Helsinki, the Academy of Finland Award for Social Impact in 2016, and the Controlled Release Society Young Investigator Award 2021.

Jian Yang

Research Center for Industries of the Future, Biomedical Engineering Program, School of Engineering, Westlake University, Hangzhou, Zhejiang, PR China

Presentation title:
Regenerative Citrate Biomaterials for Regenerative Engineering

Dr. Jian Yang is currently a Chair Professor in Biomaterials and Regenerative Engineering, the chair of Biomedical Engineering Program, and an Associate Vice President at the Westlake University (China). Prior to Westlake, he was a Professor of Biomedical Engineering and Dorothy Foehr Huck and J. Lloyd Huck Chair in Regenerative Engineering at the Pennsylvania State University (USA). Dr. Yang is known for his pioneering contribution on citrate chemistry and biology for the development and applications of citrate-based biomaterials. He was a recipient of NSF CAREER Award (2010), Outstanding Young Engineering Faculty Award at UTA (2011), PSEAS Outstanding Research Award at Penn State (2018), and BMES Wallace H. Coulter Award for Healthcare Innovation Award (2023). Dr. Yang is an elected Fellow of American Institute of Medical and Biological Engineering (AIMBE, 2016), the US National Academy of Inventors (NAI, 2018), the US Biomedical Engineering Society (BMES, 2020), the American Association for the Advancement of Science (AAAS, 2021), and the International Academy of Medical and Biological Engineering (IAMBE, 2023). Dr. Yang is the Co-Editor-in-Chief of “Bioactive Materials”, and an Associate Editor of “Science Advances”. Dr. Yang is a co-founder and the Past-President of Chinese Association for Biomaterials (CAB) and the recipient of 2023 CAB Distinguished Leadership and Service Award.

Citrate-based biodegradable polymers have emerged as a distinctive biomaterial platform with tremendous potential for diverse medical applications. By harnessing their versatile chemistry, these polymers exhibit a wide range of material and bioactive properties, enabling them to regulate cell metabolism and stem cell differentiation via metabonegenesis, angiogenesis, and immunomodulation, antioxidant, and antimicrobial capabilities. Moreover, the recent U.S. Food and Drug Administration (FDA) clearance of the biodegradable poly(octamethylene citrate)(POC)/hydroxyapatite-derived orthopedic fixation devices represents a landmark in modern biomaterials science. POC joins a short list of biodegradable synthetic polymers that have ever been authorized by the FDA for use in humans. The clinical success of POC has sparked enthusiasm and accelerated the development of next-generation citrate-based biomaterials. In this talk, the emerging frontiers of citrate-based regenerative biomaterials including new biomaterial design under the unique citrate chemistry and biology and their applications in soft and hard tissue engineering, drug delivery, in vitro and in vivo bioimaging and biosensing, and anti-counterfeiting will be discussed. The translation successes of citrate biomaterials in regenerative engineering will be highlighted.

Shengmin Zhang

Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan, China
Institute of Regulatory Science for Medical Devices, Huazhong University of Science and Technology, Wuhan, China
NMPA Research Base of Regulatory Science for Medical Devices,Huazhong University of Science and Technology, Wuhan, China

Presentation title:
New Strategy for Regenerative Medicine Based on Bioenergetic-active Materials

Professor Shengmin Zhang, Ph.D. is a world-wide leading scientist in innovative biomaterials, regenerative medicine and medical devices. Currently, He is the Dean of Institute of Regulatory Science for Medical Devices, Huazhong University of Science and Technology, Director of Research Base of Regulatory Science for Medical Devices, National Medical Products Administration, The People’s Republic of China. In addition, he is also the Chair of TERMIS-AP and the Vice President of Chinese Society for Biomaterials.

Dr. Zhang is the author/co-author of more than 120 peer review journal papers, such as National Science Review, Science Advances, Chemical Reviews, Materials Today, Nature Communications, ACS Nano, Biotechnology Advances, Biomaterials,Advanced Functional Materials, etc. Professor Zhang is the pioneer of the clinical translation of functional element-doped bone grafts and bioactive composite absorbable bone internal fixation devices found in clinic applications for more than 15 years. Up to now, his patents have been successfully translated into 7 medical devices in markets approved by CFDA/NMPA and FDA.
As the Vice President of Chinese Society for Biomaterials, Chief Expert on Science Promotion of the Association of Science and Technology of China, Dr. Zhang also contributed a lot to public policy consulting, industrial development, and public promotion of biomaterials science and engineering. He is one of few leading scientists in promoting multi-lateral international cooperation among government departments, societies, institutions, such as CFDA, FDA, KFDA, societies for biomaterials and TERM, etc.

Yufeng Zheng

School of Materials Science and Engineering, Peking University, Beijing, PR China

Presentation title:
Development of High Strength Biodegradable Metals for Regenerative

Prof. Yufeng Zheng, is a Boya Chair Professor at School of Materials Science and Engineering, Peking University, China. He received his Ph.D in materials science from Harbin Institute of Technology, China in 1998, and has taken a tenure professor position at the Peking University since 2004. Dr. Zheng has authored or co-authored over 700 scientific peer-reviewed articles, with the citation of over 43000 times, and a H-index of 102, and being recognized as 2022 and 2023 Clarivate Highly Cited Researcher. His areas of special interest include the development of new metallic biomaterials and their medical devices (biodegradable Mg, Fe, Zn and Mo based alloys, beta-Ti alloys with low elastic modulus, bulk metallic glass, ultra-fine grained metallic materials, etc). He is the Fellow of Biomaterials Science and Engineering (FBSE), International Union of Societies for Biomaterials Science and Engineering (IUSBSE), and College of Fellows, American Institute for Medical and Biological Engineering (AIMBE). Currently he serves as Editor-in-Chief of “Bioactive Materials”, Vice Editor-in-Chief of “Journal of Materials Science & Technology”, Editor of “Materials Letters”.

The lists are updated continuously.